Glossary

DHPP vaccine

The standard combination puppy and adult shot covering distemper, hepatitis (adenovirus), parainfluenza and parvovirus.

Also called: DHPP, DAPP, DA2PP, DHLPP, distemper combo, 5-in-1 shot, puppy combo vaccine

DHPP is a single combination injection. The letters stand for distemper, hepatitis (caused by canine adenovirus), parainfluenza and parvovirus. Distemper, adenovirus and parvovirus are core, and parainfluenza adds some protection against kennel cough. Different clinics write it DAPP or DA2PP, and a version with an L adds leptospirosis.

Puppies usually start between six and eight weeks old and get repeated doses every few weeks until about sixteen weeks of age or older, because maternal antibodies can interfere with earlier shots. A booster follows about a year later, and then boosters are given at intervals chosen by the vet.

DHPP does not include rabies, which is a separate legally required shot. Mild tiredness for a day is common. Swelling of the face, hives or vomiting after a shot needs a call to the clinic.

Last reviewed November 8, 2026

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Related terms

Core vaccines The vaccines veterinary guidelines recommend for virtually every dog, protecting against distemper, parvovirus, canine adenovirus and rabies. Canine distemper A serious, vaccine-preventable virus that attacks a dog's respiratory, digestive and nervous systems, and spreads through the air. Canine parvovirus A highly contagious, often deadly virus that attacks the gut and bone marrow, mainly in unvaccinated puppies, and is preventable by vaccination. Kennel cough A contagious airway infection with a dry, honking cough, caused by several viruses and bacteria and common where dogs gather.